The beneficial role of healthy microbiome in metabolic syndrome and cardiovascular health

Smriti Arora, Nitika Bhambri, Samikshha Puri, Anamika, Nandini Dasgupta, Shradha Khater, Gautam Das

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The human gut hosts approximately 10 trillion to 100 trillion microbes. Numerous studies have shown a link between these microbial cells and metabolic syndrome (MetS). MetS is a group of risk factors that increase the chances of cardiovascular and cerebrovascular diseases. MetS is characterized by increased insulin resistance, abdominal obesity, dyslipidemia, and hypertension. Studies done on animal models and human clinical trials have revealed taxonomical signatures in MetS and cardiovascular disease. Low-grade inflammation is one of the links connecting MetS to a dysbiotic gut. The link is characterized by a perturbed gut barrier, short-chain fatty acids, and branched-chain amino acids at the cellular and molecular levels. Although a link correlating MetS and gut microbiota exists, causal links have not yet been established in humans. Hence more clinical trials are needed to understand the pathogenic role of the gut in MetS and cardiovascular disease. This might help in the development of therapeutic strategies and management tools.

Original languageEnglish
Title of host publicationMicrobiome, Immunity, Digestive Health and Nutrition
Subtitle of host publicationEpidemiology, Pathophysiology, Prevention and Treatment
PublisherElsevier
Pages109-124
Number of pages16
ISBN (Electronic)9780128222386
ISBN (Print)9780128222393
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • Metabolic syndrome
  • SCFA
  • cardiovascular diseases
  • diabetes
  • diet
  • gut microbiota
  • obesity
  • prebiotic
  • probiotic

ASJC Scopus subject areas

  • General Health Professions
  • General Medicine

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