TY - JOUR
T1 - The biological effects of Auger electrons compared to α-particles and Li ions
AU - Laster, Brenda H.
AU - Shani, Gad
AU - Kahl, Stephen B.
AU - Warkentien, Lynne
N1 - Funding Information:
The authors would like to acknowledge Drs. Robert Brugger, Hunyuang B. Liu and Dennis Greenberg for their thermal beam dosimetry, Drs. V. Bond and E. Cronkite for their review of this manuscript, Ms. Amalia Ruggiero for preparing this paper, the USDOE under contract No. DE-AC02-76CH00016 for funding the in vitro studies, and the NIH under contract No. CA 37961 for funding the synthesis of BOPP. The 'OBOPP was kindly provided by Dr Stephen Kahl, University of California, San Francisco.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - V-79 Chinese hamster cell survival studies were performed which involved the stimulation of Auger electron emission in gadolinium after thermal neutron capture. When a porphyrin that had previously been labeled with boron (10BOPP) was also labeled with Gd (Gd-10BOPP), the cells were incubated with Gd-10BOPP to assess the compound's ability to physiologically transport the Gd into the cell, and localize the Gd atoms in or near the cell's critical target, presumably the DNA. It was anticipated that Auger electron emission, stimulated during the 157Gd (n, γ) 158Gd interaction, would impart additional high LET damage to that observed from the α-particle and Li ion during the 10B(n, α) 7L reaction.
AB - V-79 Chinese hamster cell survival studies were performed which involved the stimulation of Auger electron emission in gadolinium after thermal neutron capture. When a porphyrin that had previously been labeled with boron (10BOPP) was also labeled with Gd (Gd-10BOPP), the cells were incubated with Gd-10BOPP to assess the compound's ability to physiologically transport the Gd into the cell, and localize the Gd atoms in or near the cell's critical target, presumably the DNA. It was anticipated that Auger electron emission, stimulated during the 157Gd (n, γ) 158Gd interaction, would impart additional high LET damage to that observed from the α-particle and Li ion during the 10B(n, α) 7L reaction.
UR - http://www.scopus.com/inward/record.url?scp=0030466482&partnerID=8YFLogxK
U2 - 10.3109/02841869609104046
DO - 10.3109/02841869609104046
M3 - Conference article
C2 - 9004772
AN - SCOPUS:0030466482
SN - 0284-186X
VL - 35
SP - 917
EP - 923
JO - Acta Oncologica
JF - Acta Oncologica
IS - 7
T2 - Proceedings of the 1995 3rd International Symposium on Biophysical Aspects of Auger Processes
Y2 - 24 August 1995 through 25 August 1995
ER -