The biological effects of Auger electrons compared to α-particles and Li ions

Brenda H. Laster, Gad Shani, Stephen B. Kahl, Lynne Warkentien

Research output: Contribution to journalConference articlepeer-review

14 Scopus citations

Abstract

V-79 Chinese hamster cell survival studies were performed which involved the stimulation of Auger electron emission in gadolinium after thermal neutron capture. When a porphyrin that had previously been labeled with boron (10BOPP) was also labeled with Gd (Gd-10BOPP), the cells were incubated with Gd-10BOPP to assess the compound's ability to physiologically transport the Gd into the cell, and localize the Gd atoms in or near the cell's critical target, presumably the DNA. It was anticipated that Auger electron emission, stimulated during the 157Gd (n, γ) 158Gd interaction, would impart additional high LET damage to that observed from the α-particle and Li ion during the 10B(n, α) 7L reaction.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalActa Oncologica
Volume35
Issue number7
DOIs
StatePublished - 1 Jan 1996
EventProceedings of the 1995 3rd International Symposium on Biophysical Aspects of Auger Processes - Lund, Swed
Duration: 24 Aug 199525 Aug 1995

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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