The biology of lipid droplet-bound mitochondria

Michaela Veliova, Anton Petcherski, Marc Liesa, Orian S. Shirihai

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Proper regulation of cellular lipid storage and oxidation is indispensable for the maintenance of cellular energy homeostasis and health. Mitochondrial function has been shown to be a main determinant of functional lipid storage and oxidation, which is of particular interest for the adipose tissue, as it is the main site of triacylglyceride storage in lipid droplets (LDs). Recent studies have identified a subpopulation of mitochondria attached to LDs, peridroplet mitochondria (PDM) that can be separated from cytoplasmic mitochondria (CM) by centrifugation. PDM have distinct bioenergetics, proteome, cristae organization and dynamics that support LD build-up, however their role in adipose tissue biology remains largely unexplored. Therefore, understanding the molecular basis of LD homeostasis and their relationship to mitochondrial function and attachment in adipocytes is of major importance.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume108
DOIs
StatePublished - 1 Dec 2020
Externally publishedYes

Keywords

  • Adipose tissue
  • Lipid droplets
  • Lipotoxicity
  • Miochondria
  • Triacylglycerides

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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