The burden of depression in systemic sclerosis patients: a nationwide population-based study

Nicola L. Bragazzi, Abdulla Watad, Alex Gizunterman, Dennis McGonagle, Hussein Mahagna, Doron Comaneshter, Howard Amital, Arnon D. Cohen, Daniela Amital

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    Background: Systemic sclerosis (SSc) can clinically present with psychological symptoms, including pain, depression, and distress about disfigurement, physical and social functioning. The existing small studies have reported a prevalence of depression ranging from 36% to 65% among SSc patients, likely reflecting the disease impact on the patient's self-image and function. Aim of the study: To investigate the association between SSc and depression using big data analysis methods. Methods: We designed a nation-wide epidemiological survey relying on a large database of 2500 SSc patients and explored the relationship between SSc and depression, but also the impact of depression on the survival of SSc patients. Chi-squared and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. Results: The proportion rate of depression among SSc patients was significantly higher than controls (16.2% vs 10.9%), and this proportion was even higher in female SSc patients and of low socioeconomic status. At the multivariate logistic regression, SSc was found to be an independent risk factor for depression with an OR of 1.55 (95%CI 1.29–1.88, p < 0.0001). No significant association was found between SSc-specific autoantibodies (anti-centromere, anti-Scl-70, anti-RNA polymerase III and anti-RNP) status and the risk of depression. Depression was not found to have a significant impact on the survival of SSc patients with an HR of 1.06 (0.80–1.42). Conclusions: This study provides further support for the high prevalence of depression in SSc patients and therefore, SSc patients may benefit from a screening approach and a broad supportive care program.

    Original languageEnglish
    Pages (from-to)427-431
    Number of pages5
    JournalJournal of Affective Disorders
    Volume243
    DOIs
    StatePublished - 15 Jan 2019

    Keywords

    • Biological markers
    • Depression
    • Epidemiology
    • Ethnicity/race
    • Mood disorders

    ASJC Scopus subject areas

    • Clinical Psychology
    • Psychiatry and Mental health

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