TY - JOUR
T1 - The burden of depression in systemic sclerosis patients
T2 - a nationwide population-based study
AU - Bragazzi, Nicola L.
AU - Watad, Abdulla
AU - Gizunterman, Alex
AU - McGonagle, Dennis
AU - Mahagna, Hussein
AU - Comaneshter, Doron
AU - Amital, Howard
AU - Cohen, Arnon D.
AU - Amital, Daniela
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Background: Systemic sclerosis (SSc) can clinically present with psychological symptoms, including pain, depression, and distress about disfigurement, physical and social functioning. The existing small studies have reported a prevalence of depression ranging from 36% to 65% among SSc patients, likely reflecting the disease impact on the patient's self-image and function. Aim of the study: To investigate the association between SSc and depression using big data analysis methods. Methods: We designed a nation-wide epidemiological survey relying on a large database of 2500 SSc patients and explored the relationship between SSc and depression, but also the impact of depression on the survival of SSc patients. Chi-squared and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. Results: The proportion rate of depression among SSc patients was significantly higher than controls (16.2% vs 10.9%), and this proportion was even higher in female SSc patients and of low socioeconomic status. At the multivariate logistic regression, SSc was found to be an independent risk factor for depression with an OR of 1.55 (95%CI 1.29–1.88, p < 0.0001). No significant association was found between SSc-specific autoantibodies (anti-centromere, anti-Scl-70, anti-RNA polymerase III and anti-RNP) status and the risk of depression. Depression was not found to have a significant impact on the survival of SSc patients with an HR of 1.06 (0.80–1.42). Conclusions: This study provides further support for the high prevalence of depression in SSc patients and therefore, SSc patients may benefit from a screening approach and a broad supportive care program.
AB - Background: Systemic sclerosis (SSc) can clinically present with psychological symptoms, including pain, depression, and distress about disfigurement, physical and social functioning. The existing small studies have reported a prevalence of depression ranging from 36% to 65% among SSc patients, likely reflecting the disease impact on the patient's self-image and function. Aim of the study: To investigate the association between SSc and depression using big data analysis methods. Methods: We designed a nation-wide epidemiological survey relying on a large database of 2500 SSc patients and explored the relationship between SSc and depression, but also the impact of depression on the survival of SSc patients. Chi-squared and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. Results: The proportion rate of depression among SSc patients was significantly higher than controls (16.2% vs 10.9%), and this proportion was even higher in female SSc patients and of low socioeconomic status. At the multivariate logistic regression, SSc was found to be an independent risk factor for depression with an OR of 1.55 (95%CI 1.29–1.88, p < 0.0001). No significant association was found between SSc-specific autoantibodies (anti-centromere, anti-Scl-70, anti-RNA polymerase III and anti-RNP) status and the risk of depression. Depression was not found to have a significant impact on the survival of SSc patients with an HR of 1.06 (0.80–1.42). Conclusions: This study provides further support for the high prevalence of depression in SSc patients and therefore, SSc patients may benefit from a screening approach and a broad supportive care program.
KW - Biological markers
KW - Depression
KW - Epidemiology
KW - Ethnicity/race
KW - Mood disorders
UR - http://www.scopus.com/inward/record.url?scp=85054032874&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2018.09.075
DO - 10.1016/j.jad.2018.09.075
M3 - Article
AN - SCOPUS:85054032874
SN - 0165-0327
VL - 243
SP - 427
EP - 431
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -