TY - JOUR
T1 - The burden of gout in acne keloidalis nuchae—Insights from a population-based study
AU - Shavit, Eran
AU - Cohen, Arnon
AU - Zoller, Lilach
AU - Onn, Erez
AU - Kridin, Khalaf
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Background: The risk of gout amid patients with acne keloidalis nuchae (AKN) has not been investigated in the past. Objective: To assess the risk of developing gout among patients with AKN relative to control subjects. Methods: A population-based retrospective study followed patients with AKN (n = 2677) and age-, sex-, and ethnicity-matched control subjects (n = 13 190). The incidence of new-onset gout was compared between the two groups. Hazard ratio (HR) for the risk of gout was obtained using a multivariate Cox regression model. Results: The incidence rate of gout was 1.12 (95% CI, 0.68–1.76) and 0.48 (95% CI, 0.34–0.66) per 1000 person-years among patients with AKN and controls, respectively. The crude risk of developing gout was significantly higher in patients with AKN (HR, 2.27; 95% CI, 1.26–4.10; p = 0.007). After controlling for age, sex, and ethnicity, AKN emerged as an independent risk factor of gout (adjusted HR, 2.34; 95% CI, 1.29–4.22; p = 0.005). When adjusting for other confounders such as body mass index, diabetes mellitus, hypertension, and dyslipidemia, the risk of gout in AKN fell out of significance (adjusted HR, 1.39; 95% CI, 0.73–2.65; p = 0.311),. Conclusion: Patients with AKN experience an increased risk of gout. The risk is not independent and is mainly mediated through the metabolic comorbidities typifying AKN. We recommend screening for gout in patients with suggestive complaints.
AB - Background: The risk of gout amid patients with acne keloidalis nuchae (AKN) has not been investigated in the past. Objective: To assess the risk of developing gout among patients with AKN relative to control subjects. Methods: A population-based retrospective study followed patients with AKN (n = 2677) and age-, sex-, and ethnicity-matched control subjects (n = 13 190). The incidence of new-onset gout was compared between the two groups. Hazard ratio (HR) for the risk of gout was obtained using a multivariate Cox regression model. Results: The incidence rate of gout was 1.12 (95% CI, 0.68–1.76) and 0.48 (95% CI, 0.34–0.66) per 1000 person-years among patients with AKN and controls, respectively. The crude risk of developing gout was significantly higher in patients with AKN (HR, 2.27; 95% CI, 1.26–4.10; p = 0.007). After controlling for age, sex, and ethnicity, AKN emerged as an independent risk factor of gout (adjusted HR, 2.34; 95% CI, 1.29–4.22; p = 0.005). When adjusting for other confounders such as body mass index, diabetes mellitus, hypertension, and dyslipidemia, the risk of gout in AKN fell out of significance (adjusted HR, 1.39; 95% CI, 0.73–2.65; p = 0.311),. Conclusion: Patients with AKN experience an increased risk of gout. The risk is not independent and is mainly mediated through the metabolic comorbidities typifying AKN. We recommend screening for gout in patients with suggestive complaints.
KW - acne keloidalis
KW - association
KW - gout
KW - risk
UR - http://www.scopus.com/inward/record.url?scp=85141443920&partnerID=8YFLogxK
U2 - 10.1111/jocd.15476
DO - 10.1111/jocd.15476
M3 - Article
C2 - 36345820
AN - SCOPUS:85141443920
SN - 1473-2130
VL - 22
SP - 284
EP - 288
JO - Journal of Cosmetic Dermatology
JF - Journal of Cosmetic Dermatology
IS - 1
ER -