The burden of gout in acne keloidalis nuchae—Insights from a population-based study

Eran Shavit, Arnon Cohen, Lilach Zoller, Erez Onn, Khalaf Kridin

    Research output: Contribution to journalArticlepeer-review


    Background: The risk of gout amid patients with acne keloidalis nuchae (AKN) has not been investigated in the past. Objective: To assess the risk of developing gout among patients with AKN relative to control subjects. Methods: A population-based retrospective study followed patients with AKN (n = 2677) and age-, sex-, and ethnicity-matched control subjects (n = 13 190). The incidence of new-onset gout was compared between the two groups. Hazard ratio (HR) for the risk of gout was obtained using a multivariate Cox regression model. Results: The incidence rate of gout was 1.12 (95% CI, 0.68–1.76) and 0.48 (95% CI, 0.34–0.66) per 1000 person-years among patients with AKN and controls, respectively. The crude risk of developing gout was significantly higher in patients with AKN (HR, 2.27; 95% CI, 1.26–4.10; p = 0.007). After controlling for age, sex, and ethnicity, AKN emerged as an independent risk factor of gout (adjusted HR, 2.34; 95% CI, 1.29–4.22; p = 0.005). When adjusting for other confounders such as body mass index, diabetes mellitus, hypertension, and dyslipidemia, the risk of gout in AKN fell out of significance (adjusted HR, 1.39; 95% CI, 0.73–2.65; p = 0.311),. Conclusion: Patients with AKN experience an increased risk of gout. The risk is not independent and is mainly mediated through the metabolic comorbidities typifying AKN. We recommend screening for gout in patients with suggestive complaints.

    Original languageEnglish
    Pages (from-to)284-288
    Number of pages5
    JournalJournal of Cosmetic Dermatology
    Issue number1
    StatePublished - 1 Jan 2023


    • acne keloidalis
    • association
    • gout
    • risk

    ASJC Scopus subject areas

    • Dermatology


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