The C allele in NOS3-786 T/C polymorphism is associated with elite soccer player's status

N. Eynon, J. R. Ruiz, T. Yvert, C. Santiago, F. Gómez-Gallego, A. Lucia, R. Birk

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The NOS3-786 T/C polymorphism (rs2070744) is a candidate to explain individual variations in sports related phenotypes. We determined the genotype and allele frequency of NOS3-786 T/C in a group of 60 male professional elite soccer players. Their results were compared with those of 100 world-class endurance athletes, 53 elite power athletes, and 100 sedentary, healthy men (controls) of the same Caucasian (Spanish) origin. There were significant differences in genotype frequencies between soccer players, controls, endurance and power elite athletes (all P0.02). These results were confirmed when we analysed allelic frequencies (all P<0.01). The likelihood of having the C allele was higher in soccer players compared with (i) controls [odds ratio (OR), 2.165, 95% confidence interval (CI): 1.362-3.441], (ii) endurance athletes (OR: 1.879, 95%CI: 1.184-2.984), and (iii) power athletes (OR: 4.032, 95%CI: 2.307-7.047). In conclusion, the -786C allele is associated with the status of being an elite soccer player, compared with non-athletic controls and also with elite endurance and power athletes. More research is needed in other groups of elite soccer players in order to replicate the results of the present study.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalInternational Journal of Sports Medicine
Issue number7
StatePublished - 12 Jul 2012
Externally publishedYes


  • athletic performance
  • genetics
  • nitric oxide synthase
  • polymorphism

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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