The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

N. Zilberberg; E. Zlotkin; M. Gurevitz

doi:10.1016/0041-0101(91)90213-B

The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

N. Zilberberg, E. Zlotkin, M. Gurevitz

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40 Scopus citations

Abstract

N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

Original language	English
Pages (from-to)	1155-1158
Number of pages	4
Journal	Toxicon
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/0041-0101(91)90213-B
State	Published - 1 Jan 1991
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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title = "The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus",

abstract = "N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.",

author = "N. Zilberberg and E. Zlotkin and M. Gurevitz",

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AB - N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

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The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

Abstract

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