The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

N. Zilberberg; E. Zlotkin; M. Gurevitz

doi:10.1016/0041-0101(91)90213-B

The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

N. Zilberberg, E. Zlotkin, M. Gurevitz

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

Original language	English
Pages (from-to)	1155-1158
Number of pages	4
Journal	Toxicon
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/0041-0101(91)90213-B
State	Published - 1 Jan 1991
Externally published	Yes

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/0041-0101(91)90213-B

Cite this

@article{7814509af5d1469cb3a326f9b91231f4,

title = "The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus",

abstract = "N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.",

author = "N. Zilberberg and E. Zlotkin and M. Gurevitz",

note = "Funding Information: .labeowdedgementr-R+e thank U. E.1ux and J. H a for help and advice. This research was supported in part by the {"}Consorvation, Food and Health Foundation, Inc.{"}, Boston MA, U.S.A.",

year = "1991",

month = jan,

day = "1",

doi = "10.1016/0041-0101(91)90213-B",

language = "English",

volume = "29",

pages = "1155--1158",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

AU - Zilberberg, N.

AU - Zlotkin, E.

AU - Gurevitz, M.

N1 - Funding Information: .labeowdedgementr-R+e thank U. E.1ux and J. H a for help and advice. This research was supported in part by the "Consorvation, Food and Health Foundation, Inc.", Boston MA, U.S.A.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

AB - N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

UR - http://www.scopus.com/inward/record.url?scp=0025882676&partnerID=8YFLogxK

U2 - 10.1016/0041-0101(91)90213-B

DO - 10.1016/0041-0101(91)90213-B

M3 - Article

AN - SCOPUS:0025882676

SN - 0041-0101

VL - 29

SP - 1155

EP - 1158

JO - Toxicon

JF - Toxicon

IS - 9

ER -

The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this