The complete coding sequence of the human a-raf-1 oncogene and transforming activity of a human a-raf carrying retrovirus

T. W. Beck, M. Huleihel, M. Gunnell, T. I. Bonner, U. R. Rapp

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf. shows significant homology with protein kinase C. A 5′ deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.

Original languageEnglish
Pages (from-to)595-609
Number of pages15
JournalNucleic Acids Research
Volume15
Issue number2
DOIs
StatePublished - 26 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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