The complex role of SIRT6 in carcinogenesis

Batia Lerrer; Asaf A. Gertler; Haim Y. Cohen

doi:10.1093/carcin/bgv167

The complex role of SIRT6 in carcinogenesis

Batia Lerrer, Asaf A. Gertler, Haim Y. Cohen

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.

Original language	English
Pages (from-to)	108-118
Number of pages	11
Journal	Carcinogenesis
Volume	37
Issue number	2
DOIs	https://doi.org/10.1093/carcin/bgv167
State	Published - 8 Sep 2015
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/carcin/bgv167

Cite this

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title = "The complex role of SIRT6 in carcinogenesis",

abstract = "SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.",

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The complex role of SIRT6 in carcinogenesis

Abstract

ASJC Scopus subject areas

UN SDGs

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