TY - JOUR
T1 - The complexity of cellular dedifferentiation
T2 - implications for regenerative medicine
AU - Grafi, Gideon
N1 - Funding Information:
I thank Y. Avivi for critical reading of the manuscript. This work was supported by The Goldinger Trust of the Jewish Fund for the Future at the The Jewish Federation of Delaware.
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Cellular dedifferentiation underlies topical issues in biology, such as regeneration and somatic cell nuclear transfer (SCNT), and signifies the withdrawal of cells from a given differentiated state into a 'stem cell'-like state that confers pluripotency. Recently, there has been growing interest in exploiting the dedifferentiation process to obtain autologous stem cell lineages for use in regenerative medicine. This approach holds great promise, particularly in view of the ethical concerns invoked over the use of human embryonic stem cells in research and the problem of transplant rejection. However, new insights provided by the study of this process in plants and animals have highlighted the complexity and hazards of cellular dedifferentiation.
AB - Cellular dedifferentiation underlies topical issues in biology, such as regeneration and somatic cell nuclear transfer (SCNT), and signifies the withdrawal of cells from a given differentiated state into a 'stem cell'-like state that confers pluripotency. Recently, there has been growing interest in exploiting the dedifferentiation process to obtain autologous stem cell lineages for use in regenerative medicine. This approach holds great promise, particularly in view of the ethical concerns invoked over the use of human embryonic stem cells in research and the problem of transplant rejection. However, new insights provided by the study of this process in plants and animals have highlighted the complexity and hazards of cellular dedifferentiation.
UR - http://www.scopus.com/inward/record.url?scp=65549126459&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2009.02.007
DO - 10.1016/j.tibtech.2009.02.007
M3 - Article
AN - SCOPUS:65549126459
SN - 0167-7799
VL - 27
SP - 329
EP - 332
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -