The critical cortical area for development of penicillin-induced epilepsy

E. Reichenthal, S. Hocherman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The smallest (critical) size of active penicillin foci in exposed rats' brains was determined by: (a) gradual enlargement of drug application area from 0.4 to 2.5 mm2; and by (b) limitation of active penicillin foci by subpial cuts. A critical area of slightly more than 0.5 mm2 was arrived at by both techniques. The essential role of the horizontal connections in the cortical top three layers to the maintenance of epilepsy was emphasized.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
JournalElectroencephalography and Clinical Neurophysiology
Issue number2
StatePublished - 1 Jan 1977
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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