The critical cortical area for development of penicillin-induced epilepsy

E. Reichenthal; S. Hocherman

doi:10.1016/0013-4694(77)90031-1

The critical cortical area for development of penicillin-induced epilepsy

E. Reichenthal, S. Hocherman

Research output: Contribution to journal › Article › peer-review

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Abstract

The smallest (critical) size of active penicillin foci in exposed rats' brains was determined by: (a) gradual enlargement of drug application area from 0.4 to 2.5 mm²; and by (b) limitation of active penicillin foci by subpial cuts. A critical area of slightly more than 0.5 mm² was arrived at by both techniques. The essential role of the horizontal connections in the cortical top three layers to the maintenance of epilepsy was emphasized.

Original language	English
Pages (from-to)	248-251
Number of pages	4
Journal	Electroencephalography and Clinical Neurophysiology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0013-4694(77)90031-1
State	Published - 1 Jan 1977
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/0013-4694(77)90031-1

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title = "The critical cortical area for development of penicillin-induced epilepsy",

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AB - The smallest (critical) size of active penicillin foci in exposed rats' brains was determined by: (a) gradual enlargement of drug application area from 0.4 to 2.5 mm2; and by (b) limitation of active penicillin foci by subpial cuts. A critical area of slightly more than 0.5 mm2 was arrived at by both techniques. The essential role of the horizontal connections in the cortical top three layers to the maintenance of epilepsy was emphasized.

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The critical cortical area for development of penicillin-induced epilepsy

Abstract

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