The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Adi L. Tarca; Wendy Fitzgerald; Piya Chaemsaithong; Zhonghui Xu; Sonia S. Hassan; Jean Charles Grivel; Nardhy Gomez-Lopez; Bogdan Panaitescu; Percy Pacora; Eli Maymon; Offer Erez; Leonid Margolis; Roberto Romero

doi:10.1111/aji.12686

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Adi L. Tarca, Wendy Fitzgerald, Piya Chaemsaithong, Zhonghui Xu, Sonia S. Hassan, Jean Charles Grivel, Nardhy Gomez-Lopez, Bogdan Panaitescu, Percy Pacora, Eli Maymon, Offer Erez, Leonid Margolis, Roberto Romero

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Problem: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16-22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.

Original language	English
Article number	e12686
Journal	American Journal of Reproductive Immunology
Volume	78
Issue number	3
DOIs	https://doi.org/10.1111/aji.12686
State	Published - 1 Sep 2017
Externally published	Yes

Keywords

amniocentesis
cervical insufficiency
cytokine
macrophage inflammatory protein
network analysis
preterm birth

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1111/aji.12686

Cite this

Tarca, A. L., Fitzgerald, W., Chaemsaithong, P., Xu, Z., Hassan, S. S., Grivel, J. C., Gomez-Lopez, N., Panaitescu, B., Pacora, P., Maymon, E., Erez, O., Margolis, L., & Romero, R. (2017). The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. American Journal of Reproductive Immunology, 78(3), Article e12686. https://doi.org/10.1111/aji.12686

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abstract = "Problem: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16-22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.",

keywords = "amniocentesis, cervical insufficiency, cytokine, macrophage inflammatory protein, network analysis, preterm birth",

author = "Tarca, {Adi L.} and Wendy Fitzgerald and Piya Chaemsaithong and Zhonghui Xu and Hassan, {Sonia S.} and Grivel, {Jean Charles} and Nardhy Gomez-Lopez and Bogdan Panaitescu and Percy Pacora and Eli Maymon and Offer Erez and Leonid Margolis and Roberto Romero",

note = "Publisher Copyright: Published 2017. This article is a U.S. Government work and is in the public domain in the USA. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.",

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T1 - The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

AU - Tarca, Adi L.

AU - Fitzgerald, Wendy

AU - Chaemsaithong, Piya

AU - Xu, Zhonghui

AU - Hassan, Sonia S.

AU - Grivel, Jean Charles

AU - Gomez-Lopez, Nardhy

AU - Panaitescu, Bogdan

AU - Pacora, Percy

AU - Maymon, Eli

AU - Erez, Offer

AU - Margolis, Leonid

AU - Romero, Roberto

N1 - Publisher Copyright: Published 2017. This article is a U.S. Government work and is in the public domain in the USA. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Problem: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16-22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.

AB - Problem: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16-22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.

KW - amniocentesis

KW - cervical insufficiency

KW - cytokine

KW - macrophage inflammatory protein

KW - network analysis

KW - preterm birth

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ER -

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Abstract

Keywords

ASJC Scopus subject areas

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