The detection of anti-Sm-RNP activity in sera of patients with monoclonal gammopathies

M. Abu-Shakrah, M. Krupp, S. Argov, D. Buskila, H. Slor, Y. Schoenfeld

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19 Scopus citations


The sera of 141 patients with monoclonal gammopathies were examined for the presence of anti-RNP and anti-Sm activities. An enzyme-linked immunosorbent assay (ELISA) was employed. Thirty-two sera were found to bind RNP while 16 bound to Sm. The anti-Sm and anti-RNP antibodies were found in sera of patients with IgG, IgM and IgA gammopathies. The activity against RNP and/or Sm was confirmed further by using purified immunoglobulins, employing competition assays and immunoblotting. Anti-Sm antibodies are regarded as being highly specific for SLE, yet none of the patients whose serum was found to contain high titres of anti-Sm/anti-RNP antibodies presented with symptoms related to SLE or other rheumatic diseases. Our results of a high incidence of anti-ribonucleoproteins activity in the serum of patients with monoclonal gammopathies support previous reports of autoantibody properties characteristic of these immunoglobulins.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1 Jan 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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