The development of medical biosensors and nanobiosensors

Robert Steven Marks

doi:10.1016/j.copbio.2011.05.009

Abstract

We describe here the development of various technologiesdeveloped in our laboratory over the years that may be used in theclinical environment. These are based on the fields of chemistry,molecular biology, physics, data mining and chemical engineering.Most have been validated using real-life samples from Africa, Israel,USA, and South America and are discussed as follows:1. Chemiluminescence-basedfiber-opticimmunosensorstopatients infected with viral pathogens (Ebola, Dengue, Hep-aptitis C, West Nile virus, Rift Valley fever) – the BioPenconcept.2. Detection of negative stranded RNA viruses (CCHF, influenza)using reverse genetics cell sensors.3. Biochip immunosensors based on electrogenerated filmsdeposited on ITO chip surfaces.4. Label-less nanometer scale ‘nanoantenna’ immunosensors usingRaman and IR spectroscopies to Epstein Barr EBNA1 or GIPC1antigens.5. Magnetic liquid fiber guide immunosensor for GIPC1 cancer anti-gen.6. Diagnostic phagocytic chemiluminescent imprints to identify

Original language	English GB
Pages	S15-S15
DOIs	https://doi.org/10.1016/j.copbio.2011.05.009
State	Published - Sep 2011
Event	European Biotechnology Congress 2011 - Duration: 28 Sep 2011 → 1 Oct 2011

Conference

Conference	European Biotechnology Congress 2011
Period	28/09/11 → 1/10/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.copbio.2011.05.009

Cite this

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title = "The development of medical biosensors and nanobiosensors",

abstract = "We describe here the development of various technologiesdeveloped in our laboratory over the years that may be used in theclinical environment. These are based on the fields of chemistry,molecular biology, physics, data mining and chemical engineering.Most have been validated using real-life samples from Africa, Israel,USA, and South America and are discussed as follows:1. Chemiluminescence-basedfiber-opticimmunosensorstopatients infected with viral pathogens (Ebola, Dengue, Hep-aptitis C, West Nile virus, Rift Valley fever) – the BioPenconcept.2. Detection of negative stranded RNA viruses (CCHF, influenza)using reverse genetics cell sensors.3. Biochip immunosensors based on electrogenerated filmsdeposited on ITO chip surfaces.4. Label-less nanometer scale {\textquoteleft}nanoantenna{\textquoteright} immunosensors usingRaman and IR spectroscopies to Epstein Barr EBNA1 or GIPC1antigens.5. Magnetic liquid fiber guide immunosensor for GIPC1 cancer anti-gen.6. Diagnostic phagocytic chemiluminescent imprints to identify",

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