The Development of Novel Drug Treatments for Stroke Patients: A Review

Dmitry Frank, Alexander Zlotnik, Matthew Boyko, Benjamin Fredrick Gruenbaum

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Acute ischemic stroke is a critical condition that can result in disability and death. The consequences of this medical condition depend on various factors, including the size of the stroke, affected brain region, treatment onset, and the type of treatment. The primary objective of stroke treatment is to restart ischemic penumbra tissue perfusion and reduce infarct volume by sustaining blood flow. Recent research on the condition’s pathological pathways and processes has significantly improved treatment options beyond restoring perfusion. Many studies have concentrated on limiting injury severity via the manipulation of molecular mechanisms of ischemia, particularly in animal research. This article reviews completed and ongoing research on the development of acute ischemic stroke drugs. This study focuses on three main categories of antithrombotic drugs, thrombolytic drugs, and neuroprotective agents. The paper outlines findings from animal and clinical trials and explores the working mechanisms of these drugs.

Original languageEnglish
Article number5796
JournalInternational Journal of Molecular Sciences
Volume23
Issue number10
DOIs
StatePublished - 1 May 2022
Externally publishedYes

Keywords

  • acute ischemic stroke
  • antithrombotic drugs
  • neuroprotection
  • thrombolytic drugs

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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