The diagnostic and prognostic role of microRNA in colorectal cancer-a comprehensive review

Haggi Mazeh, Ido Mizrahi, Nadia Ilyayev, David Halle, Björn L.D.M. Brücher, Anton Bilchik, Mladjan Protic, Martin Daumer, Alexander Stojadinovic, Itzhak Avital, Aviram Nissan

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

The discovery of microRNA, a group of regulatory short RNA fragments, has added a new dimension to the diagnosis and management of neoplastic diseases. Differential expression of microRNA in a unique pattern in a wide range of tumor types enables researches to develop a microRNA- based assay for source identification of metastatic disease of unknown origin. This is just one example of many microRNA-based cancer diagnostic and prognostic assays in various phases of clinical research. Since colorectal cancer (CRC) is a phenotypic expression of multiple molecular pathways including chromosomal instability (CIN), micro-satellite instability (MIS) and CpG islands promoter hypermethylation (CIMP), there is no one-unique pattern of microRNA expression expected in this disease and indeed, there are multiple reports published, describing different patterns of microRNA expression in CRC. The scope of this manuscript is to provide a comprehensive review of the scientific literature describing the dysregulation of and the potential role for microRNA in the management of CRC. A Pubmed search was conducted using the following MeSH terms, "microRNA" and "colorectal cancer". Of the 493 publications screened, there were 57 papers describing dysregulation of microRNA in CRC.

Original languageEnglish
Pages (from-to)281-295
Number of pages15
JournalJournal of Cancer
Volume4
Issue number3
DOIs
StatePublished - 30 Aug 2013
Externally publishedYes

Keywords

  • Colorectal cancer
  • microRNA

ASJC Scopus subject areas

  • Oncology

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