TY - JOUR
T1 - The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis
AU - Kriķe, Petra
AU - Shums, Zakera
AU - Poļaka, Inese
AU - Kikuste, Ilze
AU - Vanags, Aigars
AU - Tolmanis, Ivars
AU - Isajevs, Sergejs
AU - Liepniece-Karele, Inta
AU - Santare, Daiga
AU - Tzivian, Lilian
AU - Rudzīte, Dace
AU - Song, Minkyo
AU - Camargo, M. Constanza
AU - Norman, Gary L.
AU - Leja, Mārcis
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application.
AB - We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application.
KW - anti-parietal cell antibodies
KW - atrophic gastritis
KW - autoimmune gastritis
KW - corpus-restricted atrophic gastritis
KW - gastrin-17
KW - intrinsic factor antibodies
KW - pepsinogens
UR - http://www.scopus.com/inward/record.url?scp=85149485152&partnerID=8YFLogxK
U2 - 10.3390/diagnostics12112784
DO - 10.3390/diagnostics12112784
M3 - Article
AN - SCOPUS:85149485152
SN - 2075-4418
VL - 12
JO - Diagnostics
JF - Diagnostics
IS - 11
M1 - 2784
ER -