The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain

A. Reches; R. P. Ebstein; R. H. Belmaker

doi:10.1007/BF00426910

The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain

A. Reches, R. P. Ebstein, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	Psychopharmacology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1007/BF00426910
State	Published - 1 Jan 1978
Externally published	Yes

Keywords

Differential inhibition
Guinea pig brain
Lithium
Noradrenaline- and dopaminesensitive cyclic AMP accumulation

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00426910

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abstract = "Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation.",

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AB - Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation.

KW - Differential inhibition

KW - Guinea pig brain

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The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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