The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain

A. Reches, R. P. Ebstein, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalPsychopharmacology
Volume58
Issue number2
DOIs
StatePublished - 1 Jan 1978
Externally publishedYes

Keywords

  • Differential inhibition
  • Guinea pig brain
  • Lithium
  • Noradrenaline- and dopaminesensitive cyclic AMP accumulation

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