The DifferentialNet database of differential protein-protein interactions in human tissues

Omer Basha, Rotem Shpringer, Chanan M. Argov, Esti Yeger-Lotem

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


DifferentialNet is a novel database that provides users with differential interactome analysis of human tissues ( Users query DifferentialNet by protein, and retrieve its differential protein-protein interactions (PPIs) per tissue via an interactive graphical interface. To compute differential PPIs, we integrated available data of experimentally detected PPIs with RNA-sequencing profiles of tens of human tissues gathered by the GenotypeTissue Expression consortium (GTEx) and by the Human Protein Atlas (HPA). We associated each PPI with a score that reflects whether its corresponding genes were expressed similarly across tissues, or were up-or down-regulated in the selected tissue. By this, users can identify tissue-specific interactions, filter out PPIs that are relatively stable across tissues, and highlight PPIs that show relative changes across tissues. The differential PPIs can be used to identify tissue-specific processes and to decipher tissue-specific phenotypes. Moreover, they unravel processes that are tissue-wide yet tailored to the specific demands of each tissue.

Original languageEnglish
Pages (from-to)D522-D526
JournalNucleic Acids Research
Issue numberD1
StatePublished - 1 Jan 2018


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