TY - JOUR
T1 - The Digital Ageing Atlas
T2 - Integrating the diversity of age-related changes into a unified resource
AU - Craig, Thomas
AU - Smelick, Chris
AU - Tacutu, Robi
AU - Wuttke, Daniel
AU - Wood, Shona H.
AU - Stanley, Henry
AU - Janssens, Georges
AU - Savitskaya, Ekaterina
AU - Moskalev, Alexey
AU - Arking, Robert
AU - De Magalhães, João Pedro
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online (http://ageing-map.org/). Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.
AB - Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online (http://ageing-map.org/). Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.
UR - http://www.scopus.com/inward/record.url?scp=84943768619&partnerID=8YFLogxK
U2 - 10.1093/nar/gku843
DO - 10.1093/nar/gku843
M3 - Article
C2 - 25232097
AN - SCOPUS:84943768619
SN - 0305-1048
VL - 43
SP - D873-D878
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -