The dual role of bacteriocins as anti- and probiotics

O. Gillor, A. Etzion, M. A. Riley

Research output: Contribution to journalShort surveypeer-review

305 Scopus citations


Bacteria employed in probiotic applications help to maintain or restore a host's natural microbial floral. The ability of probiotic bacteria to successfully outcompete undesired species is often due to, or enhanced by, the production of potent antimicrobial toxins. The most commonly encountered of these are bacteriocins, a large and functionally diverse family of antimicrobials found in all major lineages of Bacteria. Recent studies reveal that these proteinaceous toxins play a critical role in mediating competitive dynamics between bacterial strains and closely related species. The potential use of bacteriocin-producing strains as probiotic and bioprotective agents has recently received increased attention. This review will report on recent efforts involving the use of such strains, with a particular focus on emerging probiotic therapies for humans, livestock, and aquaculture.

Original languageEnglish
Pages (from-to)591-606
Number of pages16
JournalApplied Microbiology and Biotechnology
Issue number4
StatePublished - 1 Dec 2008


  • Bacteriocin
  • Gastrointestinal tract
  • Livestock
  • Oral cavity
  • Probiotic
  • Vagina

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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