The effect of acute and chronic lithium on forskolin-induced reduction of rat activity

Y. Bersudsky; Y. Patishi; J. Bitsch Jensen; A. Mørk; O. Kofman; R. H. Belmaker

doi:10.1007/BF01285562

The effect of acute and chronic lithium on forskolin-induced reduction of rat activity

Y. Bersudsky, Y. Patishi, J. Bitsch Jensen, A. Mørk, O. Kofman, R. H. Belmaker

Department of Psychology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Forskolin is a diterpene derivative that activates adenylate cyclase and raises cAMP levels in the cell. Both ip and icv forskolin cause behavioral hypoactivity. Lithium has been reported for many years to block cAMP accumulation, but the behavioral relevance of this biochemical effect is not clear. We studied the effect of acute and chronic lithium on icv forskolin-induced hypoactivity. Acute lithium had no effect, but chronic lithium significantly blocked forskolin-induced hypoactivity. The effect of chronic lithium occurred with both forskolin in DMSO and with a water-soluble forskolin derivative. These results suggest that this behavioral model can be used to investigate whether new inhibitors of adenylate cyclase possess lithium-like effects.

Original language	English
Pages (from-to)	943-952
Number of pages	10
Journal	Journal of Neural Transmission
Volume	104
Issue number	8-9
DOIs	https://doi.org/10.1007/BF01285562
State	Published - 1 Jan 1997

Keywords

Cyclic AMP
Forskolin
Lithium
Locomotor activity

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/BF01285562

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abstract = "Forskolin is a diterpene derivative that activates adenylate cyclase and raises cAMP levels in the cell. Both ip and icv forskolin cause behavioral hypoactivity. Lithium has been reported for many years to block cAMP accumulation, but the behavioral relevance of this biochemical effect is not clear. We studied the effect of acute and chronic lithium on icv forskolin-induced hypoactivity. Acute lithium had no effect, but chronic lithium significantly blocked forskolin-induced hypoactivity. The effect of chronic lithium occurred with both forskolin in DMSO and with a water-soluble forskolin derivative. These results suggest that this behavioral model can be used to investigate whether new inhibitors of adenylate cyclase possess lithium-like effects.",

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AU - Bersudsky, Y.

AU - Patishi, Y.

AU - Bitsch Jensen, J.

AU - Mørk, A.

AU - Kofman, O.

AU - Belmaker, R. H.

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N2 - Forskolin is a diterpene derivative that activates adenylate cyclase and raises cAMP levels in the cell. Both ip and icv forskolin cause behavioral hypoactivity. Lithium has been reported for many years to block cAMP accumulation, but the behavioral relevance of this biochemical effect is not clear. We studied the effect of acute and chronic lithium on icv forskolin-induced hypoactivity. Acute lithium had no effect, but chronic lithium significantly blocked forskolin-induced hypoactivity. The effect of chronic lithium occurred with both forskolin in DMSO and with a water-soluble forskolin derivative. These results suggest that this behavioral model can be used to investigate whether new inhibitors of adenylate cyclase possess lithium-like effects.

AB - Forskolin is a diterpene derivative that activates adenylate cyclase and raises cAMP levels in the cell. Both ip and icv forskolin cause behavioral hypoactivity. Lithium has been reported for many years to block cAMP accumulation, but the behavioral relevance of this biochemical effect is not clear. We studied the effect of acute and chronic lithium on icv forskolin-induced hypoactivity. Acute lithium had no effect, but chronic lithium significantly blocked forskolin-induced hypoactivity. The effect of chronic lithium occurred with both forskolin in DMSO and with a water-soluble forskolin derivative. These results suggest that this behavioral model can be used to investigate whether new inhibitors of adenylate cyclase possess lithium-like effects.

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The effect of acute and chronic lithium on forskolin-induced reduction of rat activity

Abstract

Keywords

ASJC Scopus subject areas

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