Abstract
Postexertional wheezing is an important clinical sign of nonspecific airway hyperreactivity. We have studied wheezing after exercise in 6 asthmatic subjects, 13 to 20 yr of age, using spectral analysis of recorded tracheal sounds. Automated spectral characterization was used to measure wheezing as a proportion of respiratory time. Anticholinergic treatment with ipratropium bromide (Atrovent®) was compared with placebo to investigate effects on postexertional wheezing, and pulmonary function was compared with the result of respiratory sound analysis. Atrovent did not abolish exercise-induced bronchospasm but improved preexercise lung function and thereby caused a parallel upward shift in the response curves. Wheezing after Atrovent was significantly less, later in onset, and mainly expiratory at 20 min after exercise. Wheezing as a percentage of total respiratory time correlated well with FEV1, V̇max50, and SGaw. Analysis of respiratory sounds and automated quantification of wheezing may be a useful complementary test of bronchial obstruction in asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 16-21 |
| Number of pages | 6 |
| Journal | American Review of Respiratory Disease |
| Volume | 132 |
| Issue number | 1 |
| State | Published - 19 Sep 1985 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
