The effect of dabigatran and rivaroxaban on platelet reactivity and inflammatory markers

Noa Zemer-Wassercug, Moti Haim, Dorit Leshem-Lev, Katia L. Orvin, Muthiah Vaduganathan, Ariel Gutstein, Ehud Kadmon, Aviv Mager, Ran Kornowski, Eli L. Lev

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The new oral anticoagulants (NOACs) reduce stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF), but dabigatran may increase risk of coronary ischemic events for unclear reasons. Thus, this study assessed the effects of dabigatran and rivaroxaban on platelet reactivity and inflammatory markers in patients with non-valvular AF. Patients with non-valvular AF planned to begin treatment with NOACs were included. Seventeen patients were prescribed dabigatran and ten rivaroxaban. Platelet function (as assessed by multiple-electrode aggregometry, Impact-R shear-induced platelet deposition, P-selectin expression and plasma RANTES levels) and high-sensitivity C-reactive protein (hs-CRP) were measured at enrollment (prior to initiation of NOAC treatment) and at least 7 days into treatment with either dabigratran or rivaroxaban. Seventeen patients treated with dabigatran (mean age 69 ± 7 years, 35 % women, mean CHADS2 score 2.6 ± 1.2), and ten patients treated with rivaroxaban (mean age 73 ± 9 years, 20 % women, mean CHADS2 score 2.7 ± 1.6) completed the study. In both groups, there were no significant differences in platelet reactivity between the baseline and on-anticoagulant treatment time-points, as measured by each of the platelet-specific assays. There was a trend towards increased platelet reactivity in response to arachidonic acid from baseline to on-treatment in both groups, probably as a result of aspirin discontinuation in 33 % of patients. No significant differences were noted between baseline and on-treatment in hs-CRP in both anticoagulant groups. Treatment with dabigatran and rivaroxaban does not appear to be associated with changes in markers of platelet reactivity or systemic inflammation.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalJournal of Thrombosis and Thrombolysis
Volume40
Issue number3
DOIs
StatePublished - 24 Oct 2015
Externally publishedYes

Keywords

  • Anticoagulation
  • Atrial fibrillation
  • Platelet reactivity

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