Abstract
Objective: To evaluate the relationship between endometrial thickness measured before embryo transfer, and pregnancy outcomes in frozen-thawed embryo transfer (FET). Methods: We retrospectively analyzed outcomes of all consecutive FET cycles, from January 2012 to August 2018. Based on ROC analysis for endometrial thickness, we found 8 mm was a reliable cutoff point to predict pregnancy prior to embryo transfer. Accordingly, the cycles were divided into Group A: cycles with endometrial thickness ≤ 8 mm and Group B: > 8 mm. Results: Group A included 485 FET cycles and group B included 626 cycles. Compared with group A, Group B had significantly higher chemical and clinical pregnancy rates (30.3 vs. 24.6%; p =.046, and 24.0 vs. 18.6%; p =.036), respectively. In multivariate analysis, endometrial thickness and the protocols used were the only parameters influencing the chance to achieve pregnancy, with odds ratio 1.54 (95%CI 1.07–2.22, p =.019) for the endometrium and odds ratio 1.95 (95%CI 1.31–2.9; p =.001) to the protocol used. Endometrial thickness might predict crown-rump length (CRL) discordancy with odds ratio 4.61 (p =.001; 95% CI 1.42–14.92). Compared with group B, Group A had more cases of overt discordancy (13.3 vs. 4%; p =.016). Conclusions: For patients undergoing FET cycles, endometrial thickness and treatment protocol may predict the chemical and clinical pregnancy rates, as well as CRL discordancy. Summary: Endometrial thickness and preparation improved pregnancy rate in FET cycles and significantly greater crown-rump length discordancy was observed with thinner endometria.
Original language | English |
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Pages (from-to) | 428-432 |
Number of pages | 5 |
Journal | Gynecological Endocrinology |
Volume | 37 |
Issue number | 5 |
DOIs | |
State | Published - 1 Jan 2021 |
Externally published | Yes |
Keywords
- Endometrial thickness
- crown-rump length
- endometrial pattern
- frozen embryo transfer
- pregnancy rate
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Obstetrics and Gynecology