TY - JOUR
T1 - The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate
AU - Yagel, S.
AU - Ben-Chetrit, A.
AU - Anteby, E.
AU - Zacut, D.
AU - Hochner-Celnikier, D.
AU - Ron, M.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Objective: To assess the deleterious effect of clomiphene citrate (CC) on the development of the endometrium and its improvement by the addition of ethinyl estradiol (E2). Participating Patients: Infertility-treated patients, monitored for induction of ovulation or timing of insemination (control group). Design: We studied four groups of women during an ovulatory cycle with various treatment schedules. Group 1: untreated patients; group 2: patients treated by CC; group 3: patients treated by CC + ethinyl E2; group 4: patients treated by human menopausal gonadotropin. Follow-up of the patients was done by vaginal ultrasonography and measurements of blood E2. Results: In the group treated by CC, both endometrial thickness and uterine volume growth during the follicular phase were lower as compared with untreated controls and menotropin-treated patients. The addition of ethinyl E2 to these patients reversed this deletrious effect of CC without interfering with ovulation. Conclusion: Ethinyl E2 may reverse the deleterious effect of CC on endometrial development during the follicular phase.
AB - Objective: To assess the deleterious effect of clomiphene citrate (CC) on the development of the endometrium and its improvement by the addition of ethinyl estradiol (E2). Participating Patients: Infertility-treated patients, monitored for induction of ovulation or timing of insemination (control group). Design: We studied four groups of women during an ovulatory cycle with various treatment schedules. Group 1: untreated patients; group 2: patients treated by CC; group 3: patients treated by CC + ethinyl E2; group 4: patients treated by human menopausal gonadotropin. Follow-up of the patients was done by vaginal ultrasonography and measurements of blood E2. Results: In the group treated by CC, both endometrial thickness and uterine volume growth during the follicular phase were lower as compared with untreated controls and menotropin-treated patients. The addition of ethinyl E2 to these patients reversed this deletrious effect of CC without interfering with ovulation. Conclusion: Ethinyl E2 may reverse the deleterious effect of CC on endometrial development during the follicular phase.
UR - http://www.scopus.com/inward/record.url?scp=0026602319&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)54772-4
DO - 10.1016/S0015-0282(16)54772-4
M3 - Article
AN - SCOPUS:0026602319
SN - 0015-0282
VL - 57
SP - 33
EP - 36
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -