The effect of haloperidol feeding on dopamine receptor number in ten mouse strains

R. H. Belmaker; J. Bannet; E. Brecher-Fride; J. Yanai; R. P. Ebstein

doi:10.1111/j.1399-0004.1981.tb00725.x

The effect of haloperidol feeding on dopamine receptor number in ten mouse strains

R. H. Belmaker, J. Bannet, E. Brecher-Fride, J. Yanai, R. P. Ebstein

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Mean DA receptor number in rats rises markedly after chronic haloperidol treatment, and this rise is accompanied by a significantly increased variance. The rise in DA receptor number has been proposed as a molecular model of human tardive dyskinesia. Since human tardive dyskinesia may involve pharmacogenetic susceptibility, ten inbred mouse strains were treated for 3 weeks with haloperidol and caudate DA receptor number was determined 4 days after cessation of feeding. Some strains showed much larger rises in DA receptor number than others, supporting the notion that genetic factors may be involved in the susceptibility to large DA receptor responses to chronic haloperidol.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Clinical Genetics
Volume	19
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0004.1981.tb00725.x
State	Published - 1 Jan 1981
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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AU - Yanai, J.

AU - Ebstein, R. P.

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The effect of haloperidol feeding on dopamine receptor number in ten mouse strains

Abstract

ASJC Scopus subject areas

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