Abstract
Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the β-adrenergic-stimulated adenylate cyclase. Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits β-adrenergic adenylate cyclase. In contrast, ten subjects receiving haloperidol, a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals. These findings are discussed in relation to the possible pharmacological mechanisms of action of lithium and haloperidol in the control of mania.
Original language | English |
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Pages (from-to) | 215-217 |
Number of pages | 3 |
Journal | Psychopharmacology |
Volume | 49 |
Issue number | 2 |
DOIs | |
State | Published - 1 Jan 1976 |
Externally published | Yes |
Keywords
- Adenylate cyclase
- Epinephrine
- Haloperidol
- Lithium
- Mania
ASJC Scopus subject areas
- Pharmacology