The effect of haloperidol on epinephrine-stimulated adenylate cyclase in humans

Robert H. Belmaker, Richard P. Ebstein, Helen Schoenfeld, Ranan Rimon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the β-adrenergic-stimulated adenylate cyclase. Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits β-adrenergic adenylate cyclase. In contrast, ten subjects receiving haloperidol, a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals. These findings are discussed in relation to the possible pharmacological mechanisms of action of lithium and haloperidol in the control of mania.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalPsychopharmacology
Volume49
Issue number2
DOIs
StatePublished - 1 Jan 1976
Externally publishedYes

Keywords

  • Adenylate cyclase
  • Epinephrine
  • Haloperidol
  • Lithium
  • Mania

ASJC Scopus subject areas

  • Pharmacology

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