Abstract
This paper describes the stimulation of exodus of cystine from lysosome-rich granular fractions by potassium. Potassium permeability into lysosomes is low, but in the presence of an ionophore or permeable anion, the movement of K+ into lysosomes caused a large stimulation of cystine exodus. Lysosomal preparations from leucocytes of cystinotic patients, which lack carrier-mediated cystine transport, also manifested stimulation of cystine egress by valinomycin and K+. This suggests that potassium-dependent cystine egress involves a carrier different from that defective in cystinosis, or occurs through a non-carrier-mediated mechanism.
Original language | English |
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Pages (from-to) | 267-273 |
Number of pages | 7 |
Journal | Biochimica et Biophysica Acta - Biomembranes |
Volume | 777 |
Issue number | 2 |
DOIs | |
State | Published - 7 Nov 1984 |
Externally published | Yes |
Keywords
- (Leukocyte lysosome)
- Amino acid transport
- Cystine efflux
- Cystinosis
- Ionophore
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology