The effect of l-dopa and propranolol on human CSF cyclic nucleotides

R. H. Belmaker; R. P. Ebstein; J. Biederman; R. Stern; M. Berman; H. M. van Praag

doi:10.1007/BF00427396

The effect of l-dopa and propranolol on human CSF cyclic nucleotides

R. H. Belmaker, R. P. Ebstein, J. Biederman, R. Stern, M. Berman, H. M. van Praag

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and without l-dopa therapy and schizophrenic patients before and after propranolol therapy. No effect of l-dopa or propranolol was found on CSF cyclic nucleotides. However, Parkinson patients had a 40-50% reduction of CSF cyclic AMP and a 80-90% reduction of CSF cyclic GMP compared with the schizophrenic patients. Implications of this finding are discussed.

Original language	English
Pages (from-to)	307-310
Number of pages	4
Journal	Psychopharmacology
Volume	58
Issue number	3
DOIs	https://doi.org/10.1007/BF00427396
State	Published - 1 Jan 1978
Externally published	Yes

Keywords

CSF
Cyclic AMP
Cyclic GMP
Parkinson's disease
Propranolol
Schizophrenia
l-dopa

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF00427396

Cite this

@article{557c5327952f4f208ee7a36d95fa510a,

title = "The effect of l-dopa and propranolol on human CSF cyclic nucleotides",

abstract = "Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and without l-dopa therapy and schizophrenic patients before and after propranolol therapy. No effect of l-dopa or propranolol was found on CSF cyclic nucleotides. However, Parkinson patients had a 40-50% reduction of CSF cyclic AMP and a 80-90% reduction of CSF cyclic GMP compared with the schizophrenic patients. Implications of this finding are discussed.",

keywords = "CSF, Cyclic AMP, Cyclic GMP, Parkinson's disease, Propranolol, Schizophrenia, l-dopa",

author = "Belmaker, {R. H.} and Ebstein, {R. P.} and J. Biederman and R. Stern and M. Berman and {van Praag}, {H. M.}",

year = "1978",

month = jan,

day = "1",

doi = "10.1007/BF00427396",

language = "English",

volume = "58",

pages = "307--310",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

TY - JOUR

T1 - The effect of l-dopa and propranolol on human CSF cyclic nucleotides

AU - Belmaker, R. H.

AU - Ebstein, R. P.

AU - Biederman, J.

AU - Stern, R.

AU - Berman, M.

AU - van Praag, H. M.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and without l-dopa therapy and schizophrenic patients before and after propranolol therapy. No effect of l-dopa or propranolol was found on CSF cyclic nucleotides. However, Parkinson patients had a 40-50% reduction of CSF cyclic AMP and a 80-90% reduction of CSF cyclic GMP compared with the schizophrenic patients. Implications of this finding are discussed.

AB - Human CSF cyclic AMP and cyclic GMP have been measured as possible indicators of activity of central neurotransmitter-sensitive adenylate or guanylate cyclase. In an attempt to help to identify the specific neurotransmitter systems of origin of human CSF cyclic AMP and GMP, we studied Parkinson patients with and without l-dopa therapy and schizophrenic patients before and after propranolol therapy. No effect of l-dopa or propranolol was found on CSF cyclic nucleotides. However, Parkinson patients had a 40-50% reduction of CSF cyclic AMP and a 80-90% reduction of CSF cyclic GMP compared with the schizophrenic patients. Implications of this finding are discussed.

KW - CSF

KW - Cyclic AMP

KW - Cyclic GMP

KW - Parkinson's disease

KW - Propranolol

KW - Schizophrenia

KW - l-dopa

UR - http://www.scopus.com/inward/record.url?scp=0018100483&partnerID=8YFLogxK

U2 - 10.1007/BF00427396

DO - 10.1007/BF00427396

M3 - Article

AN - SCOPUS:0018100483

SN - 0033-3158

VL - 58

SP - 307

EP - 310

JO - Psychopharmacology

JF - Psychopharmacology

IS - 3

ER -

The effect of l-dopa and propranolol on human CSF cyclic nucleotides

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this