The effect of moderate red wine consumption on 24-h blood pressure trajectory in type 2 diabetes; a six-month randomized controlled intervention trial: P802

Yftach Gepner, Y Henkin, D Schwarzfuchs, R Golan, R Durst, I Shelef, I Harman-Boehm, M Stampfer, A Rudich, I Shai

Research output: Contribution to journalMeeting Abstract

Abstract

Aims:Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a 6-month randomized controlled trial we assessed the effect of initiating moderate red wine consumption on 24h-dynamics BP, specific time-intervals of BP, and its interaction with a common genetic variant of alcohol-dehydrogenases (ADH) among patients with type-2-diabetes.

Methods:We randomly assigned 54 type-2-diabetes patients, alcohol abstainers, to initiate consumption of 150ml dry red-wine or mineral-water at dinner. Both groups were guided to adhere to Mediterranean diet, without caloric restriction. We measured 24h ambulatory-blood-pressure-monitoring (ABPM) and ADH1B polymorphism.

Results:Participants (age=57yrs;85% men;24h blood pressure=129/77mmHg) had 92% six-month retention. After 6-month intervention, average 24hr BP did not differ between the wine and water groups. The ABPM decreased in the red-wine group at midnight (3-4 hours after wine intake: systolic BP: red-wine=-10.6mmHg vs. mineral-water=+2.3mmHg; p=0.031) and the following morning at 7-9AM (systolic BP: red-wine:-6.2mmHg vs. mineral-water:+5.6mmHg; p=0.014). Among the red-wine consumers, only the individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His;rs1229984,TT, fast ethanol metabolizers), exhibited a significant decrease in mean 24h systolic BP (-8.0mmHg vs. +3.7mmHg; p=0.002) and pulse pressure (-3.8mmHg vs. +1.2mmHg; p=0.032) compared to heterozygotes and homozygous for the ADH1B*1 variant (CC, slow metabolizers). No genetic interaction was observed for the water group.

Conclusions:Initiating moderate red-wine consumption at dinner in type-2-diabetics may have modest hypotensive effects within several hours after its consumption, and the following morning. The genetic interaction uncovers a personalized/precision-medicine factor regulating the hypotensive effect of red-wine in diabetes.
Original languageEnglish GB
Pages (from-to)S179
Number of pages1
JournalEuropean Journal of Preventive Cardiology
Volume22
Issue number1
StatePublished - 14 Jun 2015

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