The effect of neoadjuvant Imatinib therapy on outcome and survival after rectal gastrointestinal stromal tumour

S. Machlenkin, I. Pinsk, H. Tulchinsky, Y. Ziv, J. Sayfan, D. Duek, M. Rabau, S. Walfisch

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Aim: The study aimed to characterize the pathological and clinical response of rectal gastrointestinal stromal tumours (GISTs) to neoadjuvant Imatinib. Method: The medical records of patients with rectal GISTs who were diagnosed and treated in five medical centres in Israel between January 2002 and January 2009 were retrospectively examined. Twelve patients who fulfilled the inclusion criteria of nonmetastatic rectal GIST for which preoperative neoadjuvant treatment with Imatinib was considered were suitable for enrollment. Results: Of the 12 patients, nine received neoadjuvant treatment with Imatinib. The three patients who had immediate surgery were excluded. There were five men and four women with a median age of 63years and a median follow up of 32months. All tumours were located in the lower two-thirds of the rectum. One patient had a complete clinical response, six had a partial response and two had stable disease. Seven patients subsequently underwent surgery; six had an R0 resection and one had an R1 resection. Three patients had recurrence. There was no disease-related mortality. The reduction in both tumour size and mitotic activity during preoperative Imatinib therapy was significant. Conclusion: Preoperative Imatinib therapy can shrink large rectal GISTs, improving the chances of successful radical surgery and decreasing the risk of considerable morbidity.

Original languageEnglish
Pages (from-to)1110-1115
Number of pages6
JournalColorectal Disease
Volume13
Issue number10
DOIs
StatePublished - 1 Oct 2011

Keywords

  • Gastrointestinal stromal tumour
  • Imatinib
  • Neoadjuvant
  • Rectum

Fingerprint

Dive into the research topics of 'The effect of neoadjuvant Imatinib therapy on outcome and survival after rectal gastrointestinal stromal tumour'. Together they form a unique fingerprint.

Cite this