The effect of psychopharmacologic prolactin releasers on lactation in sheep

E. Bass, J. Shani, Y. Givant, R. Yagil, F. G. Sulman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Recent studies with potent prolactin releasers showed that they did not enhance milk yield in cows, ewes or rats. Therefore, 14 prolactin releasers were studied in 59 lactating ewes during the fourth month of lactation, when milk yield had fallen to less than 50%, thus indicating lack of endogenous prolactin. Sum 3170, reserpine, piperacetazine, perphenazine, thiopropazate, propericiazine, P 4657 B, haloperidol, HF 2159, trifluperidol, tetrabenazine, perphenazine sulfoxide, aminopromazine, and SU 10704 were injected i.m. or i.v. for 6 consecutive days in doses of 0.005 to 2.0 mg/kg/day. Daily measuring of milk yield showed that the following 5 substances arranged in order of their activity significantly increased declining lactation in 'drying up' ewes: trifluperidol, Sum 3170, piperacetazine, P 4657 B, and perphenazine sulfoxide. This effect appeared only during the 6 day period of injection, and then faded. It did not appear in 27 controls, but appeared, however, in cross over experiments.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume211
Issue number1
StatePublished - 1 Dec 1974

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'The effect of psychopharmacologic prolactin releasers on lactation in sheep'. Together they form a unique fingerprint.

Cite this