Abstract
It has been recently reported that pyrophosphate, tri-polyphosphate, ATP and analogous ligands considerably decrease the yield of hydroxyl radicals by the Fenton reaction under conditions where [H2O2] > > [Fe(II)Ln]. It was suggested that this effect is due to the slowing down of the Fenton reaction by these ligands. This suggestion seemed surprising as polyphosphate ligands stabilize Fe(III). Indeed, a kinetic study points out that these ligands accelerate the rate of the Fenton reaction by several orders of magnitude. Thus it is suggested that the effect of the ligands on the yield of the hydroxyl radicals is due to the stabilization of the Fe(III) complexes which slows down, or inhibits, their reduction by the radicals formed in the system and thus decreases the overall yield of hydroxyl radicals.
Original language | English |
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Pages (from-to) | 669-674 |
Number of pages | 6 |
Journal | Journal of Inorganic Biochemistry |
Volume | 105 |
Issue number | 5 |
DOIs | |
State | Published - 1 May 2011 |
Keywords
- ATP
- Fenton reaction
- Iron
- Pyrophosphate
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry