The effect of pyrophosphate, tripolyphosphate and ATP on the rate of the Fenton reaction

Sandra Rachmilovich-Calis, Alexandra Masarwa, Naomi Meyerstein, Dan Meyerstein

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

It has been recently reported that pyrophosphate, tri-polyphosphate, ATP and analogous ligands considerably decrease the yield of hydroxyl radicals by the Fenton reaction under conditions where [H2O2] > > [Fe(II)Ln]. It was suggested that this effect is due to the slowing down of the Fenton reaction by these ligands. This suggestion seemed surprising as polyphosphate ligands stabilize Fe(III). Indeed, a kinetic study points out that these ligands accelerate the rate of the Fenton reaction by several orders of magnitude. Thus it is suggested that the effect of the ligands on the yield of the hydroxyl radicals is due to the stabilization of the Fe(III) complexes which slows down, or inhibits, their reduction by the radicals formed in the system and thus decreases the overall yield of hydroxyl radicals.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume105
Issue number5
DOIs
StatePublished - 1 May 2011

Keywords

  • ATP
  • Fenton reaction
  • Iron
  • Pyrophosphate

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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