Abstract
1. The effect of repeated electroconvulsive shock (ECS) treatment and chronic LiC1 feeding on calcium-dependent, K+-evoked release of [3H] norepinephrine from rat cortical vesicular preparation was studied. 2. There was no significant effect of either acute or repeated ECS treatment on [3H]norepinephrine release in cortical vesicles obtained from animals treated for either 1 or 10 days. Release of norepinephrine was examined over a range of CaCl2 concentrations. 3. Clonidine effectively inhibited release of [3H]norepinephrine in cortical vesicles obtained from control and ECS-treated animals. 4. K+-evoked release of [3H]norepinephrine at low (0.2 m M) and high (1.0 m M) CaCl2 concentrations was significantly increased in cortical vesicles obtained from LiCl-treated animals. Clonidine effectively inhibited release of [3H]norepinephrine in cortical vesicles obtained from both control and LiCl-fed animals. 5. These results suggest a possible common mechanism of action of antidepressant drug therapy on presynaptic release of norepinephrine from nerve terminals.
Original language | English |
---|---|
Pages (from-to) | 191-201 |
Number of pages | 11 |
Journal | Cellular and Molecular Neurobiology |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - 1 Sep 1983 |
Externally published | Yes |
Keywords
- K-evoked release
- clonidine
- cortical vesicles
- electroconvulsive shock
- lithium
- norepinephrine
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology