The effect of riboflavin - Ultraviolet A-induced collagen cross-linking on intraocular pressure measurement: An experimental study

Eitan Livny, Igor Kaiserman, Naama Hammel, Tami Livnat, David Zadok, Kremer Israel, Irit Bahar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: To investigate the effect of corneal collagen cross-linking (CCL) on tonopen measurements of intraocular pressure (IOP). Methods: CCL with 0.1% riboflavin solution and 30 min of ultraviolet A radiation was performed on the right eye of 15 New Zealand albino adult rabbits (1.8-2.4 kg) (15 eyes). The left eye served as control. IOP was measured by a pressure transducer system (true IOP) and by the tonopen hand-held device (corneal applanation tonometer) before treatment, at 1 week, 1 month and 3 months following CCL. Reference pressure in the globe was increased by increments of 10 mm Hg from 10 to 40 mm Hg, using an anterior chamber infusion on a stand with variable height, and tonopen IOP measurements were recorded for each reference pressure in both eyes. Results: Before CCL, tonopen readings were similar between the two eyes (p>0.05). Tonopen underestimated the true IOP in all cases. Following CCL treatment, IOP measurements were significantly higher in the treated eye, at all time intervals (0.005<p<0.03). The most significant difference between true and measured IOP was noted at a reference pressure of 20 mm Hg. Conclusions: IOP measurements following CCL are overestimated by the tonopen, probably due to increased stiffness of the treated cornea.

Original languageEnglish
Pages (from-to)1029-1033
Number of pages5
JournalBritish Journal of Ophthalmology
Volume96
Issue number7
DOIs
StatePublished - 1 Jul 2012
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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