Radioactive very low density lipoprotein (VLDL) was prepared by perfusion in vitro of livers isolated from normal fed male and female rats with [1-14C] oleate or [9, 10-3H] oleate, respectively. These VLDL, whose properties differed due to sex, were mixed. Aliquots of the mixture were injected intravenously into fasted male and female rats and the decay of the radioactivity (14C and 3H) was measured. Disappearance of radioactivity from plasma triglyceride was more rapid in female animals. Plasma half-life of 14C and 3H was 42.5±3.7 and 49.7±4.4 minutes, respectively, when the VLDL mixture was injected into male rats. The corresponding values in female rats were 28.3±1.1 and 30.7±1.7, respectively. These data suggest strongly that the rate of utilization of VLDL triglyceride fatty acid is more rapid in the female than in the male, and that the properties of the VLDL particles are of less importance than innate sex differences in the recipient for the rate of clearance of triglyceride fatty acids.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - 27 Oct 1975|