TY - JOUR
T1 - The Effect of Single Intravenous Doses of Cimetidine Or Ranitidine on Gastric-secretion
AU - Frank, WO
AU - Peace, KE
AU - Watson, M
AU - Seaman, JJ
AU - Szego, PL
AU - Braverman, A
AU - Mico, B
AU - Dickson, B
PY - 1986/12
Y1 - 1986/12
N2 - Intravenous Cimetidine, 300 mg or 400 mg, or ranitidine, 50 mg, was administered as a single dose to 36 volunteers in a randomized, crossover fashion. Aspirates of gastric juice were obtained after dosing, and the pH, titratable acidity, gastric fluid volume, and gastric acid output were determined from baseline through 7½ hours for each subject. Each intervention significantly increased pH and suppressed hydrogen ion concentration, gastric fluid volume, and gastric acid output. Both the magnitudes of the changes when compared with baseline and the time of the mean maximum effects were similar in all three drug regimens. The effect of all three interventions on gastric fluid volume and gastric acid output diminished sharply after 6 hours. The data indicate that the gastric secretory response to all three interventions did not differ substantially.
AB - Intravenous Cimetidine, 300 mg or 400 mg, or ranitidine, 50 mg, was administered as a single dose to 36 volunteers in a randomized, crossover fashion. Aspirates of gastric juice were obtained after dosing, and the pH, titratable acidity, gastric fluid volume, and gastric acid output were determined from baseline through 7½ hours for each subject. Each intervention significantly increased pH and suppressed hydrogen ion concentration, gastric fluid volume, and gastric acid output. Both the magnitudes of the changes when compared with baseline and the time of the mean maximum effects were similar in all three drug regimens. The effect of all three interventions on gastric fluid volume and gastric acid output diminished sharply after 6 hours. The data indicate that the gastric secretory response to all three interventions did not differ substantially.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=bgu-pure&SrcAuth=WosAPI&KeyUT=WOS:A1986F386800011&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1038/clpt.1986.242
DO - 10.1038/clpt.1986.242
M3 - Article
C2 - 3780128
SN - 0009-9236
VL - 40
SP - 665
EP - 672
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 6
ER -