The effect of Vitamin C for point-of-care blood analysis applications using an electrochemical biosensor

Hadar Ben-Yoav, Sheryl E. Chocron, Thomas E. Winkler, Eunkyoung Kim, Gregory F. Payne, Reza Ghodssi, Deanna L. Kelly

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


This paper reports on an experimental study of the ability to use ascorbic acid as a reducing agent for a clozapine (CLZ) biosensor based on redox cycling electrochemistry. Ascorbic acid, which is naturally present in the blood serum, was related to the current reducing mediator, hexaammineruthenium(III) (Ru). The performance of these two candidate compounds was compared using cyclic voltammetry in the range of -0.4 to 0.7 V at scan rates of 10 mV/s. Results from bare gold electrodes indicate an electrochemical interference on the CLZ signal in the presence of ascorbic acid but no interference in the presence of Ru. Ascorbic acid was further integrated in an electrochemical biosensor comprised of gold electrodes modified with electrodeposited chitosan hydrogel and grafted catechol moieties. This modification improves CLZ sensing by amplifying its electrochemical signal by a factor of nine, compared to bare electrodes. When measured with the modified electrodes, neither ascorbic acid nor Ru affect the performance of the CLZ biosensor. Ru demonstrated a 1.5 times higher amplification of the CLZ peak current signal compared to that of ascorbic acid.

Original languageEnglish
Title of host publicationIEEE SENSORS 2013 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers
ISBN (Print)9781467346405
StatePublished - 1 Jan 2013
Externally publishedYes
Event12th IEEE SENSORS 2013 Conference - Baltimore, MD, United States
Duration: 4 Nov 20136 Nov 2013

Publication series

NameProceedings of IEEE Sensors


Conference12th IEEE SENSORS 2013 Conference
Country/TerritoryUnited States
CityBaltimore, MD

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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