We measured maximal static inspiratory and expiratory pressures (P(Imax) and P(Emax)) in 25 patients with cystic fibrosis (CF) and 80 normal control subjects to determine whether chronic hyperinflation and malnutrition reduce P(Imax) and P(Imax)/P(Emax), respectively. In addition, we examined the effect of posture on pressure generated. We used a diminution in P(Emax) as an index of a malnutrition effect on pressures generated. The patients with CF, although significantly hyperinflated (ratio of residual volume to total lung capacity, 0.49), generated P(Imax) values similar to those of the control subjects (p > 0.05). Despite evidence of malnutrition (mean body mass percentile, 78%) the P(Emax) values of patients with CF and those of control subjects were comparable (p > 0.05). There was no postural effect on pressures generated in the normal subjects or the CF group as a whole. We conclude that respiratory muscle strength is normal or supranormal in CF, despite chronic hyperinflation and malnutrition.
|Number of pages||4|
|Journal||American Review of Respiratory Disease|
|State||Published - 1 Dec 1983|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine