The effects of chronic lithium and ECT on A1 and A2 adenosine receptor systems in rat brain

Michael Newman; Joseph Zohar; Moshe Kalian; R. H. Belmaker

doi:10.1016/0006-8993(84)90670-X

The effects of chronic lithium and ECT on A₁ and A₂ adenosine receptor systems in rat brain

Michael Newman, Joseph Zohar, Moshe Kalian, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The influence of chronic dietary lithium administration and electroconvulsive therapy on adenosine A₁ and A₂ receptors in rat brain were determined. A₂ receptor activity was measured by accumulation of cyclic AMP in a cerebral cortical slice preparation after in vitro addition of 2-chloro-adenosine, and was unchanged in animals which received chronic Li but reduced following chronic ECT. A similar reduction was found in the response to noradrenaline and a combination of the two agents. A₁ receptors were measured by binding of [³H]cyclohexyladenosine. Both K_d and B_max values were unchanged after chronic Li or a single ECS, but chronic ECT led to a 70% increase in B_max. It is proposed that this effect may mediate the reduced locomotor activity seen after chronic ECT in rats, and that it may also be related to the increase in seizure thresholds seen during a course of ECS treatment in humans.

Original language	English
Pages (from-to)	188-192
Number of pages	5
Journal	Brain Research
Volume	291
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90670-X
State	Published - 16 Jan 1984
Externally published	Yes

Keywords

[H]cyclohexyladenosine binding
adenosine
electroconvulsive therapy
lithium
noradrenaline induced cyclic AMP

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10.1016/0006-8993(84)90670-X

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abstract = "The influence of chronic dietary lithium administration and electroconvulsive therapy on adenosine A1 and A2 receptors in rat brain were determined. A2 receptor activity was measured by accumulation of cyclic AMP in a cerebral cortical slice preparation after in vitro addition of 2-chloro-adenosine, and was unchanged in animals which received chronic Li but reduced following chronic ECT. A similar reduction was found in the response to noradrenaline and a combination of the two agents. A1 receptors were measured by binding of [3H]cyclohexyladenosine. Both Kd and Bmax values were unchanged after chronic Li or a single ECS, but chronic ECT led to a 70% increase in Bmax. It is proposed that this effect may mediate the reduced locomotor activity seen after chronic ECT in rats, and that it may also be related to the increase in seizure thresholds seen during a course of ECS treatment in humans.",

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AU - Newman, Michael

AU - Zohar, Joseph

AU - Kalian, Moshe

AU - Belmaker, R. H.

PY - 1984/1/16

Y1 - 1984/1/16

N2 - The influence of chronic dietary lithium administration and electroconvulsive therapy on adenosine A1 and A2 receptors in rat brain were determined. A2 receptor activity was measured by accumulation of cyclic AMP in a cerebral cortical slice preparation after in vitro addition of 2-chloro-adenosine, and was unchanged in animals which received chronic Li but reduced following chronic ECT. A similar reduction was found in the response to noradrenaline and a combination of the two agents. A1 receptors were measured by binding of [3H]cyclohexyladenosine. Both Kd and Bmax values were unchanged after chronic Li or a single ECS, but chronic ECT led to a 70% increase in Bmax. It is proposed that this effect may mediate the reduced locomotor activity seen after chronic ECT in rats, and that it may also be related to the increase in seizure thresholds seen during a course of ECS treatment in humans.

AB - The influence of chronic dietary lithium administration and electroconvulsive therapy on adenosine A1 and A2 receptors in rat brain were determined. A2 receptor activity was measured by accumulation of cyclic AMP in a cerebral cortical slice preparation after in vitro addition of 2-chloro-adenosine, and was unchanged in animals which received chronic Li but reduced following chronic ECT. A similar reduction was found in the response to noradrenaline and a combination of the two agents. A1 receptors were measured by binding of [3H]cyclohexyladenosine. Both Kd and Bmax values were unchanged after chronic Li or a single ECS, but chronic ECT led to a 70% increase in Bmax. It is proposed that this effect may mediate the reduced locomotor activity seen after chronic ECT in rats, and that it may also be related to the increase in seizure thresholds seen during a course of ECS treatment in humans.

KW - [H]cyclohexyladenosine binding

KW - adenosine

KW - electroconvulsive therapy

KW - lithium

KW - noradrenaline induced cyclic AMP

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The effects of chronic lithium and ECT on A₁ and A₂ adenosine receptor systems in rat brain

Abstract

Keywords

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