The effects of estrus cycle on drug metabolism in the rat

Y. Brandstetter, J. Kaplanski, V. Leibson, Z. Ben-Zvi

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12 Scopus citations


The effect of the female rat estral cycle on microsomal drug metabolism in-vivo and in-vitro has been studied. Two microsomal enzymes, aminopyrine-N-demethylase and aniline hydroxylase showed a greater specific activity (p<0.01 ) in the diestrus phase of the estral cycle while the oxidative enzyme aryl hydrocarbon hydroxylase and the conjugative enzyme, glucuronyl transferase, were not affected. In vivo studies which included theophylline and antipyrine metabolism, and hexobarbital sleeping times showed no difference between the different phases of the estral cycle. Conflicting evidence about the effect of steroid sex hormones on hepatic drug metabolism is discussed.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Issue number4
StatePublished - 1 Oct 1986


  • Estrus cycle
  • aminopyrine-Ndemethylase
  • aniline hydroxylase
  • antipyrine pharmacokinetics
  • aryl hydrocarbon hydroxylase


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