The effects of hemodialysis on blood glutamate levels in chronic renal failure: Implementation for neuroprotection

Boris Rogachev, Sharon Ohayon, Amit Saad, Victoria Vorobiovsky, Benjamin F. Gruenbaum, Akiva Leibowitz, Matthew Boyko, Yoram Shapira, Alla Shnaider, Moshe Zlotnik, Abed N. Azab, Alexander Zlotnik

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Purpose: The purpose of the present study is to investigate whether hemodialysis (HD) is effective in lowering blood glutamate levels. In addition, we examined the effect of HD on glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in the blood and described the rate and pattern of blood glutamate clearance during HD. Materials and Methods: Blood samples were taken from 45 patients with stage V chronic kidney disease immediately after initiation of HD and hourly, for a total of 5 blood samples. Samples were sent for determination of glutamate, glucose, GOT, GPT, hemoglobin, hematocrit, urea, and creatinine levels. A blood sample from 25 healthy volunteers without chronic renal failure was used as a control for the determination of baseline blood levels of glutamate, GOT, and GPT. Results: Glutamate and GPT levels in patients on HD were higher at baseline compared with healthy controls (P < .001). In the first 3 hours after HD, there was a decrease in blood glutamate levels compared with baseline levels (P < .00001). At the fourth hour, there was an increase in blood glutamate levels compared with the third hour (P < .05). Conclusions: Hemodialysis may be a promising method of reducing blood glutamate levels.

Original languageEnglish
Pages (from-to)743.e1-743.e7
JournalJournal of Critical Care
Volume27
Issue number6
DOIs
StatePublished - 1 Jan 2012

Keywords

  • Brain injury
  • Glutamate
  • Glutamate oxaloacetate transaminase (GOT)
  • Glutamate pyruvate transaminase (GPT)
  • Hemodialysis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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