The effects of prolonged deep freezing on the biomechanical properties of osteochondral allografts

Benjamin Rozen, Tamar Brosh, Moshe Salai, Amir Herman, Israel Dudkiewicz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Musculo-skeletal allografts sterilized and deep frozen are among the most common human tissue to be preserved and utilized in modern medicine. The effects of a long deep freezing period on cortical bone has already been evaluated and found to be insignificant. However, there are no reports about the influences of a protracted deep freezing period on osteochondral allografts. One hundred osteochondral cylinders were taken from a fresh specimen and humeral heads of 1 year, 2 years, 3 years and 4 year old bones. Twenty chips from each period, with a minimum of 3 chips per humeral head. Each was mechanically tested by 3 point compression. The fresh osteochondral allografts were significantly mechanically better than the deep frozen osteochondral allografts. There was no statistical significant time dependent difference between the deep frozen groups in relation to the freezing period. Therefore, we conclude that, from the mechanical point of view deep freezing of osteochondral allografts over a period of 4 years, is safe without further deterioration of the biomechanical properties of the osteochondral allografts.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalCell and Tissue Banking
Volume10
Issue number1
DOIs
StatePublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Biomechanical properties
  • Osteochondral allografts
  • Prolonged deep freezing

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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