The emerging role of major regulatory RNAs in cancer control

Xiaofeng Dai, Aman Chandra Kaushik, Jianying Zhang

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Alterations and personal variations of RNA interactions have been mechanistically coupled with disease etiology and phenotypical variations. RNA biomarkers, RNA mimics, and RNA antagonists have been developed for diagnostic, prognostic, and therapeutic uses. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are two major types of RNA molecules with regulatory roles, deregulation of which has been implicated in the initiation and progression of many human malignancies. Accumulating evidence indicated the clinical roles of regulatory RNAs in cancer control, stimulating a surge in exploring the functionalities of regulatory RNAs for improved understanding on disease pathogenesis and management. In this review, we highlight the critical roles of lncRNAs and miRNAs played in tumorigenesis, scrutinize their potential functionalities as diagnostic/prognostic biomarkers and/or therapeutic targets in clinics, outline opportunities that ncRNAs may bring to complement current clinical practice for improved cancer management and identify challenges faced by translating frontier knowledge on non-coding RNAs (ncRNAs) to bedside clinics as well as possible solutions.

Original languageEnglish
Article number920
JournalFrontiers in Oncology
Volume9
Issue numberSEP
DOIs
StatePublished - 1 Sep 2019
Externally publishedYes

Keywords

  • Biomarker
  • Cancer
  • Long non-coding RNA
  • Therapeutics
  • microRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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