The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li+ efflux

Rachel Levy; Reuven Zimlichman; Arie Keynan; Avinoam Livne

doi:10.1016/0005-2736(82)90102-X

The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li⁺ efflux

Rachel Levy, Reuven Zimlichman, Arie Keynan, Avinoam Livne

Department of Clinical Biochemistry and Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The rate of ouabain-resistant Li⁺-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (K_a = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li⁺ efflux and significant changes in the temperature repsonse, with essentially a single slope (K_a = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	685
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(82)90102-X
State	Published - 23 Feb 1982

Keywords

(Human erythrocyte membrane)
Hypertension
Li efflux
Temperature dependence

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Access to Document

10.1016/0005-2736(82)90102-X

Cite this

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abstract = "The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.",

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AB - The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

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