The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li+ efflux

Rachel Levy, Reuven Zimlichman, Arie Keynan, Avinoam Livne

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13 Scopus citations

Abstract

The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalBiochimica et Biophysica Acta - Biomembranes
Volume685
Issue number2
DOIs
StatePublished - 23 Feb 1982

Keywords

  • (Human erythrocyte membrane)
  • Hypertension
  • Li efflux
  • Temperature dependence

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