The Escherichia coli CRISPR system protects from λ lysogenization, lysogens, and prophage induction

Rotem Edgar; Udi Qimron

doi:10.1128/JB.00644-10

The Escherichia coli CRISPR system protects from λ lysogenization, lysogens, and prophage induction

Rotem Edgar, Udi Qimron

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, that the CRISPR system does not require noncytoplasmic elements, and that the system protects from phages entering and exiting the lysogenic cycle.

Original language	English
Pages (from-to)	6291-6294
Number of pages	4
Journal	Journal of Bacteriology
Volume	192
Issue number	23
DOIs	https://doi.org/10.1128/JB.00644-10
State	Published - 1 Dec 2010
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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abstract = "We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, that the CRISPR system does not require noncytoplasmic elements, and that the system protects from phages entering and exiting the lysogenic cycle.",

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AB - We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, that the CRISPR system does not require noncytoplasmic elements, and that the system protects from phages entering and exiting the lysogenic cycle.

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The Escherichia coli CRISPR system protects from λ lysogenization, lysogens, and prophage induction

Abstract

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