The eyes in diabetes and diabetes through the eyes

Ilana Harman-Boehm, Tomas Sosna, Henrik Lund-Andersen, Massimo Porta

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Diabetic retinopathy (DR) is the most common of the microvascular complications of diabetes. Left unchecked and untreated, it could progresses from a non-proliferative phase to a proliferative, sight-threatening phase. Macular edema which also threatens sight can appear at any stage. The pathophysiological mechanisms underlying its appearance and progression include the accumulation of plyols, advanced glycation endproducts (AGE) reactive oxygen species, release of local growth factors and activation of protein kinase C, all of which lead to structural and functional changes in the retina which can progress to threaten sight. Tight glucose and blood pressure control can prevent the appearance and progression of retinopathy. Novel PKC inhibitors, inhibitors of growth factors, blockers of the renin-angiotensin system (RAS) as well as statins can slow the progression of DR and protect sight.

Original languageEnglish
Pages (from-to)S51-S58
JournalDiabetes Research and Clinical Practice
Volume78
Issue number3 SUPPL.
DOIs
StatePublished - 20 Dec 2007
Externally publishedYes

Keywords

  • AGE
  • Diabetic retinopathy
  • Microvascular complications
  • Polyols
  • Protein kinase C
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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