The eyes in diabetes and diabetes through the eyes

Ilana Harman-Boehm; Tomas Sosna; Henrik Lund-Andersen; Massimo Porta

doi:10.1016/j.diabres.2007.09.023

The eyes in diabetes and diabetes through the eyes

Ilana Harman-Boehm, Tomas Sosna, Henrik Lund-Andersen, Massimo Porta

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Diabetic retinopathy (DR) is the most common of the microvascular complications of diabetes. Left unchecked and untreated, it could progresses from a non-proliferative phase to a proliferative, sight-threatening phase. Macular edema which also threatens sight can appear at any stage. The pathophysiological mechanisms underlying its appearance and progression include the accumulation of plyols, advanced glycation endproducts (AGE) reactive oxygen species, release of local growth factors and activation of protein kinase C, all of which lead to structural and functional changes in the retina which can progress to threaten sight. Tight glucose and blood pressure control can prevent the appearance and progression of retinopathy. Novel PKC inhibitors, inhibitors of growth factors, blockers of the renin-angiotensin system (RAS) as well as statins can slow the progression of DR and protect sight.

Original language	English
Pages (from-to)	S51-S58
Journal	Diabetes Research and Clinical Practice
Volume	78
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.diabres.2007.09.023
State	Published - 20 Dec 2007

Keywords

AGE
Diabetic retinopathy
Microvascular complications
Polyols
Protein kinase C
Renin-angiotensin system

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2007.09.023

Cite this

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title = "The eyes in diabetes and diabetes through the eyes",

abstract = "Diabetic retinopathy (DR) is the most common of the microvascular complications of diabetes. Left unchecked and untreated, it could progresses from a non-proliferative phase to a proliferative, sight-threatening phase. Macular edema which also threatens sight can appear at any stage. The pathophysiological mechanisms underlying its appearance and progression include the accumulation of plyols, advanced glycation endproducts (AGE) reactive oxygen species, release of local growth factors and activation of protein kinase C, all of which lead to structural and functional changes in the retina which can progress to threaten sight. Tight glucose and blood pressure control can prevent the appearance and progression of retinopathy. Novel PKC inhibitors, inhibitors of growth factors, blockers of the renin-angiotensin system (RAS) as well as statins can slow the progression of DR and protect sight.",

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T1 - The eyes in diabetes and diabetes through the eyes

AU - Harman-Boehm, Ilana

AU - Sosna, Tomas

AU - Lund-Andersen, Henrik

AU - Porta, Massimo

PY - 2007/12/20

Y1 - 2007/12/20

N2 - Diabetic retinopathy (DR) is the most common of the microvascular complications of diabetes. Left unchecked and untreated, it could progresses from a non-proliferative phase to a proliferative, sight-threatening phase. Macular edema which also threatens sight can appear at any stage. The pathophysiological mechanisms underlying its appearance and progression include the accumulation of plyols, advanced glycation endproducts (AGE) reactive oxygen species, release of local growth factors and activation of protein kinase C, all of which lead to structural and functional changes in the retina which can progress to threaten sight. Tight glucose and blood pressure control can prevent the appearance and progression of retinopathy. Novel PKC inhibitors, inhibitors of growth factors, blockers of the renin-angiotensin system (RAS) as well as statins can slow the progression of DR and protect sight.

AB - Diabetic retinopathy (DR) is the most common of the microvascular complications of diabetes. Left unchecked and untreated, it could progresses from a non-proliferative phase to a proliferative, sight-threatening phase. Macular edema which also threatens sight can appear at any stage. The pathophysiological mechanisms underlying its appearance and progression include the accumulation of plyols, advanced glycation endproducts (AGE) reactive oxygen species, release of local growth factors and activation of protein kinase C, all of which lead to structural and functional changes in the retina which can progress to threaten sight. Tight glucose and blood pressure control can prevent the appearance and progression of retinopathy. Novel PKC inhibitors, inhibitors of growth factors, blockers of the renin-angiotensin system (RAS) as well as statins can slow the progression of DR and protect sight.

KW - AGE

KW - Diabetic retinopathy

KW - Microvascular complications

KW - Polyols

KW - Protein kinase C

KW - Renin-angiotensin system

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SP - S51-S58

JO - Diabetes Research and Clinical Practice

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IS - 3 SUPPL.

ER -

The eyes in diabetes and diabetes through the eyes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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